Studies on Sabin Vaccine Administration in Nagaoka City in 1960.

Improvement in the yield of oral poliovirus vaccine (Sabin strains) produced in human diploid cells

Stabilizing effect of magnesium chloride and sucrose on Sabin live polio vaccine

[History of development of the live poliomyelitis vaccine from Sabin attenuated strains in 1959 and idea of poliomyelitis eradication].

In 1958 Poliomyelitis Institute in Moscow and Institute of Experimental Medicine in St. Petersburg received from A. Sabin the attenuated strains of poliomyelitis virus. The characteristics of the strains were thoroughly studied by A. A. Smorodintsev and coworkers. They found that the virulence of the strains fluctuated slightly in 10 consecutive passages through the intestine of the non-immune ...

Safety and immunogenicity of inactivated poliovirus vaccine made from Sabin strains: a phase II, randomized, positive-controlled trial.

BACKGROUND The production of Sabin inactivated poliovirus vaccine (IPV) can reduce biosafety requirements in the posteradication/post-oral poliovirus vaccine (OPV) era. We conducted a phase II, randomized, positive-controlled trial to assess the safety and immunogenicity of Sabin IPV. METHODS The test groups (A, B, and C) received 3 doses of high, middle, and low D antigen (D Ag) of Sabin IPV...

II. Scope, Planning, and Initial Steps §

The Middletown Project was undertaken as a combined trial and demonstration of how the Sabin oral poliovirus vaccine could be given on a city-wide, simultaneous or mass basis in an urban American community of approximately 30,000 population. Specific objectives were multiple. They included: the assessment of the immunological effectiveness of this immunizing agent when given in such a setting; ...