Serum Endotoxins and Flagellin and Risk of Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) Cohort.
نویسندگان
چکیده
BACKGROUND Chronic inflammation and oxidative stress are thought to be involved in colorectal cancer development. These processes may contribute to leakage of bacterial products, such as lipopolysaccharide (LPS) and flagellin, across the gut barrier. The objective of this study, nested within a prospective cohort, was to examine associations between circulating LPS and flagellin serum antibody levels and colorectal cancer risk. METHODS A total of 1,065 incident colorectal cancer cases (colon, n = 667; rectal, n = 398) were matched (1:1) to control subjects. Serum flagellin- and LPS-specific IgA and IgG levels were quantitated by ELISA. Multivariable conditional logistic regression models were used to calculate ORs and 95% confidence intervals (CI), adjusting for multiple relevant confouding factors. RESULTS Overall, elevated anti-LPS and anti-flagellin biomarker levels were not associated with colorectal cancer risk. After testing potential interactions by various factors relevant for colorectal cancer risk and anti-LPS and anti-flagellin, sex was identified as a statistically significant interaction factor (Pinteraction < 0.05 for all the biomarkers). Analyses stratified by sex showed a statistically significant positive colorectal cancer risk association for men (fully-adjusted OR for highest vs. lowest quartile for total anti-LPS + flagellin, 1.66; 95% CI, 1.10-2.51; Ptrend, 0.049), whereas a borderline statistically significant inverse association was observed for women (fully-adjusted OR, 0.70; 95% CI, 0.47-1.02; Ptrend, 0.18). CONCLUSION In this prospective study on European populations, we found bacterial exposure levels to be positively associated to colorectal cancer risk among men, whereas in women, a possible inverse association may exist. IMPACT Further studies are warranted to better clarify these preliminary observations.
منابع مشابه
Fish may protect against colorectal cancer
Adults from ten European countries have been questioned about their dietary habits and lifestyles since 1992 for the EPIC trial (European Prospective Investigation into Cancer and Nutrition). Epidemiologists at the International Agency for Research on Cancer (IARC) in Lyon, France, which coordinates EPIC, and colleagues from other EPIC study centres, assessed the relationship between meat and f...
متن کاملDoes ethnicity affect survival following colorectal cancer? A prospective, cohort study using Iranian cancer registry
Background:The present study compared the differences between survivals of patients with colorectal cancer according to their ethnicity adjusted for other predictors of survival. Methods: In this prospective cohort study patients were followed up from definite diagnosis of colorectal cancer to death. Totally, 2431 person-year follow-ups were undertaken for 1127 colorectal cancer patients on...
متن کاملEPIC Project European Prospective Investigation into Cancer and Nutrition
The report by WCRF / AICR (2007) concluded that high intake of processed meat convincingly increases the risk of colorectal cancer (CCR). In relation to esophageal (EA) and gastric cancer (GC) the report judged evidence as limited-suggestive. Previous results from EPIC have shown that processed meat PM is a risk factor for CCR (Norat, JNCI, 2005) and GC (González, JNCI 2006). Moreover, a prelim...
متن کاملDietary Total Antioxidant Capacity and Colorectal Cancer in the Italian EPIC Cohort
BACKGROUND Colorectal cancer is the third most common cancer worldwide. Diet has been hypothesized as involved in colorectal cancer etiology, but few studies on the influence of total dietary antioxidant intake on colorectal cancer risk have been performed. METHODS We investigated the association between colorectal cancer risk and the total antioxidant capacity (TAC) of the diet, and also of ...
متن کاملDiet and cancer prevention: where we are, where we are going.
The European Prospective Investigation into Cancer and Nutrition (EPIC) was specifically designed to investigate the relationship between diet and cancer, with the aims of making a significant contribution to the accumulated scientific knowledge, trying to overcoming limitations of previous study. We present the most relevant results obtained so far for the most frequent cancer sites. EPIC is a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
دوره 25 2 شماره
صفحات -
تاریخ انتشار 2016