Quality of life and survival of patients with malignant bile duct obstruction following different ERCP based treatments

Objective: This study aimed to investigate quality of life and survival of patients with malignant bile duct obstruction after different endoscopic retrograde cholangiopancreatography (ERCP)-based treatments. Methods: A total of 41 patients with malignant bile duct obstruction were treated by ERCP with nasal biliary drainage, ERCP with endoscopic stent insertion, or ERCP combined with radiotherapy/chemotherapy. Results: The risk factors of quality of life in malignant obstructive jaundice patients included bilirubin, CA199, CEA, ALP and γ-GT. TBIL of ≥ 100 μmol/L, CA19-9 of ≥ 200 U/ml, ALP of ≥ 200 U/ml and γ-GT of ≥ 200 U/ml predicted a poor quality of life duration hospitalization. After ERCP, the score of role emotional (RE) significantly increased in ERCP combined with radiotherapy/chemotherapy group. The survival curve showed the median survival time was 10.2 months. The median survival time following ERCP with nasal biliary drainage, ERCP with endoscopic stent insertion and ERCP combined with radiotherapy/chemotherapy was 8.2 months, 8.2 months and 18.3 months, respectively. The median survival time in patients aged < 60 years, with bilirubin of < 100 μmol/L, CA199 of < 200 U/ml, ALP of < 200 U/L, or GGT of < 200 U/L had a longer survival time and higher survival rate. Conclusion: ERCP combined with radiotherapy/ chemotherapy may be more effective in improving quality of life and prolonging survival time.