Energy Balance After Sodium Glucose Cotransporter 2 (SGLT2) Inhibition
نویسندگان
چکیده
Eighty-six patients with type 2 diabetes (HbA1c = 7.86 0.8% [62 6 9 mmol/mol], estimated glomerular filtration rate [eGFR] = 89 6 19 mL · min · 1.73 m) received empagliflozin (25 mg/day) for 90 weeks with frequent (n = 11) assessments of body weight, eGFR, and fasting plasma glucose (FPG). Time-dependent glucose filtration was calculated as the product of eGFR and FPG; time-dependent glycosuria was estimated from previous direct measurements. The relation of calorie-to-weight changes was estimated using a mathematical model of human energy metabolism that simulates the time course of weight change for a given change in calorie balance and calculates the corresponding energy intake changes.
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