Roles of Thrombin and Platelet Membrane Glycoprotein lIb / Illa in Platelet - Subendothelial Deposition After Angioplasty in an Ex Vivo Whole Artery Model
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چکیده
Background. Platelet deposition at the site of injury caused by balloon angioplasty is associated with acute closure and restenosis. Methods and Results. In a new ex vivo whole artery angioplasty model, we examined the roles of thrombin inhibition with D-Phe-Pro-ArgCH2C1 (PPACK) and inhibition of the platelet membrane fibrinogen receptor glycoprotein lIb/Illa (GPIIb/IIIa) with monoclonal antibody 7E3 on platelet deposition at the site of balloon injury. Fresh rabbit aortas were mounted in a perfusion chamber. One half of the mounted arterial segment was dilated with a standard angioplasty balloon catheter and the uninjured half served as the control segment. The vessels
منابع مشابه
Roles of thrombin and platelet membrane glycoprotein IIb/IIIa in platelet-subendothelial deposition after angioplasty in an ex vivo whole artery model.
BACKGROUND Platelet deposition at the site of injury caused by balloon angioplasty is associated with acute closure and restenosis. METHODS AND RESULTS In a new ex vivo whole artery angioplasty model, we examined the roles of thrombin inhibition with D-Phe-Pro-ArgCH2Cl (PPACK) and inhibition of the platelet membrane fibrinogen receptor glycoprotein IIb/IIIa (GPIIb/IIIa) with monoclonal antibo...
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تاریخ انتشار 2005