Ocular adverse effects associated with cyclooxygenase-2 inhibitors.

نویسندگان

  • Frederick W Fraunfelder
  • Jonathan Solomon
  • Thomas J Mehelas
چکیده

1. Zimmerman LE, Garron LK. Melanocytoma of the optic disc. Int Ophthalmol Clin. 1962;2: 431-440. 2. Joffe L, Shields JA, Osher RH, Gass JD. Clinical and follow-up studies of melanocytomas of the optic disc. Ophthalmology. 1979;86:10671083. 3. Spencer WH. XXXIV Edward Jackson Memorial Lecture: drusen of the optic disc and aberrant axoplasmic transport. Ophthalmology. 1978;85:21-38. 4. Osher RH, Shields JA, Layman PR. Pupillary and visual field evaluation in patients with melanocytoma of the optic disc. Arch Ophthalmol. 1979;97:1096-1099. 5. Shields JA, Shields CL, Eagle RC Jr, Singh AD, Berrocal MH, Berrocal JA. Central retinal vascular obstruction secondary to melanocytoma of the optic disc. Arch Ophthalmol. 2001;119: 129-133. 6. Croxatto JO, Ebner R, Crovetto L, Morales AG. Angle closure glaucoma as initial manifestation of melanocytoma of the optic disc. Ophthalmology. 1983;90:830-834. 7. Zimmerman LE. Melanocytes, melanocytic nevi, and melanocytomas. Invest Ophthalmol. 1965; 34:11-41. 8. Takahashi T, Isayama Y, Okuzawa I. Unusual case of melanocytoma in optic disk. Jpn J Ophthalmol. 1984;28:171-175. 9. Lessell S, Cohen MM. Phosphenes induced by sound. Neurology. 1979;29:1524-1526. 10. Page NG, Bolger JP, Sanders MD. Auditory evoked phosphenes in optic nerve disease. J Neurol Neurosurg Psychiatry. 1982;45:7-12.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Selective COX-2 Inhibitors: A Review of Their Structure-Activity Relationships

Non-steroidal anti-inflammatory drugs (NSAIDs) are the competitive inhibitors of cyclooxygenase (COX), the enzyme which mediates the bioconversion of arachidonic acid to inflammatory prostaglandins (PGs). Their use is associated with the side effects such as gastrointestinal and renal toxicity. The therapeutic anti-inflammatory action of NSAIDs is produced by the inhibition of COX-2, while the ...

متن کامل

Selective COX-2 Inhibitors: A Review of Their Structure-Activity Relationships

Non-steroidal anti-inflammatory drugs (NSAIDs) are the competitive inhibitors of cyclooxygenase (COX), the enzyme which mediates the bioconversion of arachidonic acid to inflammatory prostaglandins (PGs). Their use is associated with the side effects such as gastrointestinal and renal toxicity. The therapeutic anti-inflammatory action of NSAIDs is produced by the inhibition of COX-2, while the ...

متن کامل

Ocular Inflammation and Nsaids: an Overview with Selective and Non-selective Cox Inhibitors

Inflammation is a complex biological response and like other parts of the body, ocular inflammation could have untoward effects on vision if not detected and/or diagnosed early. NSAIDs are the major ocular therapeutics for treating such eye inflammations and preferred over corticosteroids. NSAIDs are given orally as well as topically to treat ocular inflammations, however topical route is prefe...

متن کامل

Cyclooxygenase inhibitors combined with deuterium-enriched water augment cytotoxicity in A549 lung cancer cell line via activation of apoptosis and MAPK pathways

Objective(s): Combination chemotherapy is a rational strategy to increase patient response and tolerability and to decrease adverse effects and drug resistance. Recently, the use of non-steroidal anti-inflammatory drugs (NSAIDs) has been reported to be associated with reduction in occurrence of a variety of cancers including lung cancer. On the other hand, growing evidences suggest that deuteri...

متن کامل

Rho Kinase Inhibitors as a Novel Treatment for Glaucoma and Ocular Hypertension

In an elegant example of bench-to-bedside research, a hypothesis that cells in the outflow pathway actively regulate conventional outflow resistance was proposed in the 1990s and systematically pursued, exposing novel cellular and molecular mechanisms of intraocular pressure (IOP) regulation. The critical discovery that pharmacologic manipulation of the cytoskeleton of outflow pathway cells dec...

متن کامل

Assessment of the Effects of Cyclooxygenase Inhibitors on the Immune Status Following Surgery in Adult Male Rats

Background and Objectives: Surgery via different mechanisms causes immunosuppression in the post-operative period. The aim of the present study was to investigate the effects of preoperative administration of cyclooxygenase inhibitors on blood levels of Interleukin-2 (IL-2), Interferon-γ (IFN-γ), Tumor Necrosis Factor-α (TNF-α), white blood cells (WBCs) and lymphocytes. Methods: Seventy-five ma...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Archives of ophthalmology

دوره 124 2  شماره 

صفحات  -

تاریخ انتشار 2006