LYMPHOID NEOPLASIA Pegylated arginase I: a potential therapeutic approach in T-ALL
نویسندگان
چکیده
1Tumor Immunology Program, Stanley S. Scott Cancer Center, Louisiana State University–Health Sciences Center (LSU-HSC), New Orleans; 2Department of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA; 3Department of Pediatrics, LSU-HSC, New Orleans; 4School of Public Health, Louisiana State University, New Orleans; 5Ochsner Clinic Foundation, New Orleans, LA; and 6Department of Microbiology, Immunology and Parasitology, LSU-HSC, New Orleans
منابع مشابه
Pegylated arginase I: a potential therapeutic approach in T-ALL.
Adult patients with acute lymphoblastic T cell leukemia (T-ALL) have a very poor prognosis and few effective therapeutic options. Therefore, novel therapies that increase the efficacy of the treatments and that prolong T-ALL patient survival are needed. Malignant T cells require high concentrations of nutrients to sustain their increased rate of proliferation. In this study, we determined wheth...
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Arginine is a semi-essential amino acid that plays a key role in cell survival and proliferation in normal and malignant cells. BCT-100, a pegylated (PEG) recombinant human arginase, can deplete arginine and starve malignant cells of the amino acid. Acute lymphoblastic leukemia (ALL) is the most common cancer of childhood, yet for patients with high risk or relapsed disease prognosis remains po...
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Myeloid suppressor cells (MSCs) producing high levels of arginase I block T cell function by depleting l-arginine in cancer, chronic infections, and trauma patients. In cancer, MSCs infiltrating tumors and in circulation are an important mechanism for tumor evasion and impair the therapeutic potential of cancer immunotherapies. However, the mechanisms that induce arginase I in MSCs in cancer ar...
متن کاملVincristine could partly suppress stromal support to T-ALL blasts during pegylated arginase I treatment
BACKGROUND Relapsed T-lineage acute lymphoblastic leukemia (T-ALL) has been an incurable disease. Recent reports showed that an L-arginine depleting enzyme, pegylated arginase (BCT-100) may be effective against T-ALL cells. On the other hand, studies including ours had shown the symbiosis of ALL blasts and human mesenchymal stromal cells (hMSCs) in bone marrow microenvironment during L-asparagi...
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Arginase deficiency is caused by deficiency of arginase 1 (ARG1), a urea cycle enzyme that converts arginine to ornithine. Clinical features of arginase deficiency include elevated plasma arginine levels, spastic diplegia, intellectual disability, seizures and growth deficiency. Unlike other urea cycle disorders, recurrent hyperammonemia is typically less severe in this disorder. Normalization ...
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