Selected MALDI Imaging Publications
ثبت نشده
چکیده
منابع مشابه
MALDI Tissue Imaging of Drugs with the ultraflex MALDI TOF/TOF
MALDI-TOF MS has previously been used for imaging of large peptides and proteins embedded in tissue sections. This imaging technique is not limited to larger molecules, but can also be used to measure the presence of small molecules directly from tissue. However, for small molecule imaging the method of choice is a selected reaction monitoring approach in MS/MS mode.The benefits of parent ion i...
متن کاملNew developments in MALDI imaging for pathology proteomic studies.
With new emerging mass spectrometry technologies, it can now be demonstrated that direct tissue analysis is feasible using matrix-assisted laser desorption/ionization (MALDI) sources. A major advantage of direct MALDI analysis is to avoid time-consuming extraction, purification or separation steps, which have the potential for producing artifacts. Direct MALDI analysis of tissue sections enable...
متن کاملMALDI in-source decay, from sequencing to imaging.
Matrix-assisted laser desorption/ionization (MALDI) is now a mature method allowing the identification and, more challenging, the quantification of biopolymers (proteins, nucleic acids, glycans, etc). MALDI spectra show mostly intact singly charged ions. To obtain fragments, the activation of singly charged precursors is necessary, but not efficient above 3.5 kDa, thus making MALDI MS/MS diffic...
متن کاملMolecular MALDI imaging: an emerging technology for neuroscience studies.
Mass spectrometry (MS) has become an essential tool for the detection, identification, and characterization of the molecular components of biological processes, such as those responsible for the dynamic properties of the nervous system. Generally, the application of these powerful techniques requires the destruction of the specimen under study, but recent technological advances have made it pos...
متن کاملOn-tissue protein identification and imaging by MALDI-ion mobility mass spectrometry.
MALDI imaging mass spectrometry (MALDI-IMS) has become a powerful tool for the detection and localization of drugs, proteins, and lipids on-tissue. Nevertheless, this approach can only perform identification of low mass molecules as lipids, pharmaceuticals, and peptides. In this article, a combination of approaches for the detection and imaging of proteins and their identification directly on-t...
متن کامل