Phase II Studies of Docetaxel in the Treatment of Various Solid Tumours
نویسندگان
چکیده
منابع مشابه
Phase II studies of docetaxel in the treatment of various solid tumours. EORTC Early Clinical Trials Group and the EORTC Soft Tissue and Bone Sarcoma Group.
Docetaxel has been evaluated in six tumour types in a total of 189 patients entered into phase II studies. Treatment consisted of a 1 h intravenous infusion of docetaxel 100 mg/m2 repeated every 3 weeks. No premedication was administered for possible hypersensitivity reactions. Docetaxel was found to be effective as first-line chemotherapy for head and neck cancer (response rate 44%) gastric ca...
متن کاملSolid phase extraction of trace cobalt (II) in industrial wastewaters by modified nanotube carbon carboxyl and its determination with flame atomic spectroscopy
Applying a simple and selective sample preparation procedure prior to instrumental analysis is the most important and crucial step in an analytical process. Up to now, various sample preparation techniques based on solid phase extraction (SPE) systems have been developed to isolate various types of analytes from different matrices. In the method presented for preconcentration and measurement of...
متن کاملSolid phase extraction of trace cobalt (II) in industrial wastewaters by modified nanotube carbon carboxyl and its determination with flame atomic spectroscopy
Applying a simple and selective sample preparation procedure prior to instrumental analysis is the most important and crucial step in an analytical process. Up to now, various sample preparation techniques based on solid phase extraction (SPE) systems have been developed to isolate various types of analytes from different matrices. In the method presented for preconcentration and measurement of...
متن کاملA Phase II Study of Docetaxel in Patients with Relapsed and Refractory Ewing's Tumours
Purpose. The prognosis for patients with Ewing's tumours who have metastases at presentation or who are refractory to standard chemotherapy regimens remains poor. There is therefore a need to evaluate the role of new agents. This report describes the initial results of a prospective phase II trial of docetaxel in patients with progressive or refractory Ewing's tumours.Patients and methods. Four...
متن کاملDocetaxel in combination with fluorouracil for advanced solid tumors.
The results from preclinical studies using murine tumor models show that the combination of docetaxel (Taxotere) and fluorouracil (5-FU) is highly synergistic. Phase I studies in patients with advanced solid tumors indicate that 60 mg/m2 of docetaxel administered as a 1-hour intravenous infusion followed by a daily intravenous bolus of 300 mg/m2 of 5-FU on days 1 through 5 is the recommended do...
متن کامل