Stealth Adaptation of Viruses: Implications forTherapy and for Potential Toxicity of Vaccines

The scope of human and animal virology research is likely to undergo a major expansion. It will occur with the realization that the immune system may fail to effectively recognize derivative viruses, which no longer express the major antigens normally targeted by cytotoxic T lymphocytes (CTL). This immune evasion mechanism has been termed stealth adaptation. Persistent infections with stealth adapted viruses can lead to various illnesses and especially those with neuropsychiatric symptoms. Certain stealth adapted viruses almost certainly entered into humans via monkey cytomegalovirus contaminated polio vaccines. Preexisting stealth adapted virus infections may render individuals susceptible to disease provocation from administered vaccines. On a more promising note, the research has helped identify an alternative cellular energy (ACE) pathway that can suppress both stealth adapted and conventional viruses. The ACE pathway is providing a new therapeutic paradigm that extends beyond virology to general medicine. It is also leading towards a basic understanding of how Nature prevents the fusion of opposite electrical charges. It is postulated that Nature does so through a fundamental force, tentatively termed KELEA (kinetic energy limiting electrostatic attraction).