Chemical modification of PA-48153C, a novel immunosuppressant isolated from Streptomyces prunicolor PA-48153.

نویسندگان

  • K Yasui
  • Y Tamura
  • T Nakatani
  • I Horibe
  • K Kawada
  • K Koizumi
  • R Suzuki
  • M Ohtani
چکیده

5beta-Methoxy (20), 14-methyl (24), 14,14-dibromo-15-nor (25), 8-O-acyl (26-45), 8-O-alkyl (46), 8-O-alkoxycarbonyl (47, 48), and 8-O-carbamoyl (49) derivatives of PA-48153C, a novel immunosuppressant isolated from fermentation products of Streptomyces prunicolor PA-48153, were prepared. These compounds were found to retain the inhibitory activity on the responses of both T and B cells to mitogens. Among them, the C-8 hexanoate 28 showed potent suppressive effects on mitogen responses with less cytotoxicity to EL4 cells and was selected for in vivo evaluation.

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عنوان ژورنال:
  • The Journal of antibiotics

دوره 49 2  شماره 

صفحات  -

تاریخ انتشار 1996