Bioavailability and Bioequivalence Issues Associated With Oral Anticancer Drugs and Effect on Drug Market
نویسنده
چکیده
Since the past decade, drug shortage is becoming the major concern for pharmaceutical markets and it is even more in case of anticancer drugs [1,2]. Comparatively very less number of anticancer drugs is available in the current markets and various factors affecting shortage can be attributed to every stage such as drug discovery, development, conducting clinical trials and design of generic drugs. Professional health care organizations such as ASCO, ASHP and federal agencies such as FDA also stated that drug shortage will have strong negative impact on oncology [1,2].These limitations are found at higher levels especially in oral anticancer drugs because of their bioavailability issues.
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