The Accommodation Roles of Arginine in Cerebral Palsy Infants with Muscle Hypotonia

To analyze the relationship between arginine and blood ammonia, nutritional status, immunity, and to explore the regulating function of arginine in cerebral palsy infants with muscle hypotonia. We chose 96 cases with muscle hypotonia cerebral palsy from January 2009 to January 2012 in rehabilitation center of Zhengzhou children hospital as the research object, using the questionnaire survey to record the clinical symptoms, blood biochemical and blood tandem mass spectrum detection to understand arginine metabolism and biochemical indicators, and analyzed the relationship between blood arginine with nutritional status, immunity; also to analyze the regulating function of supplemental arginine in cerebral palsy infants with muscle hypotonia. In 96 cases, we detected 63 cases (65.63%) with reduced content of arginine; 52 of which include high blood ammonia, there is a negative correlation between them (r=-0.776,P=0.776); 42 of which with lower immunity, there is a positive correlation between them (r=0.351,P=0.351). There was statistical significance in the motor function, nutritional status, and the immunity function following supplement with arginine compared with the control group (P<0.05). Children with low blood arginine are often accompanied by high blood ammonia and low immunity. They also have symptoms, such as vomit, infection, and feeding difficulties, affecting the children's mental state, immune function and exercise tolerance ability. Supplement with arginine improves immune function, motor function and rehabilitation therapy. [Jihua Z, Caiyun M, Guanghui L, Qing S, Jingjie L, Chao X. The Accommodation Roles of Arginine in Cerebral Palsy Infants with Muscle Hypotonia. Life Sci J 2014;11(6):698-703] (ISSN:1097-8135). http://www.lifesciencesite.com. 106