Alteration of the Alkaloid Profile in Genetically Modified Tobacco Reveals a Role of Methylenetetrahydrofolate Reductase in Nicotine N-Demethylation1[C][W][OA]
نویسندگان
چکیده
Department of Pharmaceutical Sciences, Biomanufacturing Research Institute and Technology Enterprise, North Carolina Central University, Durham, North Carolina 27707 (C.-Y.H., F.S.K., B.M.H., J.X.); Department of Agronomy, Zhejiang University, Hangzhou 310029, China (L.F., J.Q., S.T.); Institute of Biological Chemistry, Washington State University, Pullman, Washington 99164 (K.S., S.R.); Yunnan Academy of Tobacco Agricultural Sciences, Yuxi 653100, China (B.X.); United States Department of Agriculture-Agricultural Research Service Plant Science Research Unit and Department of Crop Science, North Carolina State University, Raleigh, North Carolina 27695 (K.O.B.); Department of Plant and Soil Sciences, University of Kentucky, Lexington, Kentucky 40546 (L.P.B.); and AgriTech Interface, Chapel Hill, North Carolina 27516 (M.A.C.)
منابع مشابه
Alteration of the alkaloid profile in genetically modified tobacco reveals a role of methylenetetrahydrofolate reductase in nicotine N-demethylation.
Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme of the tetrahydrofolate (THF)-mediated one-carbon (C1) metabolic network. This enzyme catalyzes the reduction of 5,10-methylene-THF to 5-methyl-THF. The latter donates its methyl group to homocysteine, forming methionine, which is then used for the synthesis of S-adenosyl-methionine, a universal methyl donor for numerous methylation re...
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