Rapid Publications p2-Microglobulin-Deficient NOD Mice Do Not Develop Insulitis or Diabetes
نویسندگان
چکیده
The role of CD8 T-cells in the development of diabetes in the nonobese diabetic (NOD) mouse remains controversial. Although it is widely agreed that class II-restricted CD4 T-cells are essential for the development of diabetes in the NOD model, some studies have suggested that CD8 T-cells are not required for p-cell destruction. To assess the contribution of CD8 T-cells to diabetes, we have developed a class of NOD mouse that lacks expression of p2-microglobulin (N0D-S2m). NOD-S^m""" mice, which lack both class I expression and CD8 T-cells in the periphery, not only failed to develop diabetes but were completely devoid of insulitis. These results demonstrate an essential role for CD8 T-cells in the initiation of the autoimmune response to p-cells in the NOD mouse. Diabetes 43:500-504, 1994
منابع مشابه
Major histocompatibility complex class I-deficient NOD-B2mnull mice are diabetes and insulitis resistant.
Specific allelic combinations within the class II region of the major histocompatibility complex (MHC) represent a major genetic component for susceptibility to autoimmune insulin-dependent diabetes mellitus (IDDM) in humans. We produced and used a stock of NOD/Lt mice congenic for a functionally inactivated beta 2-microglobulin (B2mnull) locus to assess whether there was an absolute requiremen...
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