Effects of frusemide on human airway epithelium.
نویسندگان
چکیده
3. Dolovich M, Vanzielegham M, Hidinger K-G, Newhouse MT. Influence of inspiratory flow rate on the response to terbutaline sulphate inhaled via the Turbuhaler. Am Rev Respir Dis, 1988, 137, A433. 4. Engel T, Heinig JH, Madsen F, Weeke B, Nikander K. Peak inspiratory flow rate and inspiratory vital capacity of patients with asthma, measured with and wilhout Turbuhaler. Proceedings of European Academy of Allergology and Clinical Immunology, Copenhagen, 1988. 5. Pedersen S, Hansen OR, Fuglsang G. Influence of inspiratory flow rate upon lhe effect of a Turbuhaler. Arch Dis Childhood, 1990, 65, 308-310.
منابع مشابه
Effect of loop diuretics on cholinergic neurotransmission in human airways in vitro.
BACKGROUND Frusemide can inhibit various indirectly acting bronchoconstrictor stimuli in asthmatic patients. Both frusemide and bumetanide also modulate airway neurotransmission in some species but there are no data on the effect of loop diuretics on neurotransmission in man. An in vitro study was performed in human airways to investigate the possible neuromodulatory action of two loop diuretic...
متن کاملDifferent effects of inhaled amiloride and frusemide on airway responsiveness to dry air challenge in asthmatic subjects.
Amiloride, a Na+ channel blocker, and frusemide, an inhibitor of the Na+/K+/2Cl- co-transporter on the basolateral surface of airway epithelial cells, have the potential to affect water transport across the airway epithelium. As isocapnic hyperventilation challenge (ISH) with dry air may provoke airway narrowing in asthmatic subjects by dehydrating the airways, inhaled amiloride and frusemide m...
متن کاملChanges in neurokinin A (NKA) airway responsiveness with inhaled frusemide in asthma.
BACKGROUND Inhaled frusemide exerts a protective effect against bronchoconstriction induced by several indirect stimuli in asthma which could be due to interference of airway nerves. A randomised, double blind, placebo controlled study was performed to investigate the effect of the potent loop diuretic, frusemide, administered by inhalation on the bronchoconstrictor response to neurokinin A (NK...
متن کاملInhibition of sodium metabisulphite induced bronchoconstriction by frusemide in asthma: role of cyclooxygenase products.
BACKGROUND Inhaled frusemide inhibits airway responses to sodium metabisulphite and other indirect bronchial challenges in asthma by undetermined mechanisms which may relate to its ability to stimulate prostaglandin release. Inhalation of sodium metabisulphite provokes indirect bronchoconstriction, possibly by activating sensory nerves. To investigate the role of cyclooxygenase products in the ...
متن کاملInhaled frusemide does not affect lung mucociliary clearance in healthy and asthmatic subjects.
Inhaled frusemide has been shown to protect against the bronchoconstrictor effect of several inhaled agents in asthmatic subjects by mechanism(s) that are unclear. Since loop diuretics can modulate Cl- transport in the airway epithelium, frusemide may alter the quality and/or the quantity of the periciliary layer, which in turn may affect lung mucociliary transport. We investigated the effect o...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The European respiratory journal
دوره 3 10 شماره
صفحات -
تاریخ انتشار 1990