Integration of Pharmacokinetic and Pharmacodynamic Indices of Marbofloxacin in Turkeys Running title: PK-PD of marbofloxacin in turkeys
نویسندگان
چکیده
1. Department of Veterinary Pharmacology, Pharmacy and Toxicology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands 2. Department of Pharmacology, Physiology and Chemistry, Faculty of Veterinary Medicine, Trakia University, Bulgaria 3. Department of Microbiology, Infectious and Parasitic Diseases, Section of Microbiology, Faculty of Veterinary Medicine, Trakia University, Bulgaria
منابع مشابه
Integration of pharmacokinetic and pharmacodynamic indices of marbofloxacin in turkeys.
Fluoroquinolones are extensively used in the treatment of systemic bacterial infections in poultry, including systemic Escherichia coli bacillosis, which is a common disease in turkey flocks. Marbofloxacin has been licensed for use in various mammalian species, but not as yet for turkeys, although its kinetic properties distinguish it from other fluoroquinolones. For example, the longer half-li...
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BACKGROUND Marbofloxacin is a veterinary fluoroquinolone with high activity against Pasteurella multocida. We evaluated it's in vivo activity against P. multocida based on in vivo time-kill data in swine using a tissue-cage model. A series of dosages ranging from 0.15 to 2.5 mg/kg were administered intramuscularly after challenge with P. multocida type B, serotype 2. RESULTS The ratio of the ...
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The aim of this study was to evaluate the activity of marbofloxacin and establish the optimal dose regimens for decreasing the development of fluoroquinolone resistance in pigs against Escherichia coli with ex vivo pharmacokinetic/pharmacodynamic (PK/PD) modeling. The recommended dose (2 mg/kg body weight) of marbofloxacin was orally administered in healthy pigs. The ileum content and plasma we...
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Marbofloxacin is a fluoroquinolone specially developed for use in veterinary medicine with broad-spectrum antibacterial activity. The objective of our study was to re-evaluate in vivo antimicrobial activity of marbofloxacin against Pasteurella multocida using subcutaneously implanted tissue cages in calves. Calves were infected by direct injection into tissue cages with P. multocida(type B, ser...
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BACKGROUND Haemophilus parasuis (H. parasuis) can invade the body and cause systemic infection under stress conditions. Marbofloxacin has been recommended for the treatment of swine infections. However, few studies have investigated the PK/PD characteristics and PK/PD cutoff (COPD) of this drug against H. parasuis. RESULTS MICs of marbofloxacin against 198 H. parasuis isolates were determined...
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