Differing relationship of nocturnal fluid shifts to sleep apnea in men and women with heart failure.

نویسندگان

  • Takatoshi Kasai
  • Shveta S Motwani
  • Dai Yumino
  • Susanna Mak
  • Gary E Newton
  • T Douglas Bradley
چکیده

BACKGROUND In men with heart failure, nocturnal rostral fluid shift is associated with an overnight increase in the neck circumference (NC) and with severity of obstructive sleep apnea. Because the prevalence of obstructive sleep apnea is lower in women than in men with heart failure, we hypothesized that less fluid would shift into the neck in association with less severe obstructive sleep apnea in women than in men with heart failure. METHODS AND RESULTS In 35 men and 30 women with heart failure, we assessed overnight changes in NC (ΔNC) and leg fluid volume before and after polysomnography. The severity of obstructive sleep apnea was assessed by the apnea-hypopnea index. Although the changes in leg fluid volume did not differ significantly between men and women (-131 ± 90 versus -180 ± 132 mL, P=0.081), in women, ΔNC was smaller (P<0.001) than in men. Furthermore, although in men, changes in leg fluid volume correlated inversely with ΔNC (r=-0.755, P<0.001) and apnea-hypopnea index (r=-0.765, P<0.001), it did not in women. CONCLUSIONS Despite no difference in overnight displacement of fluid from the legs compared with in men, in women, less of this fluid reached the neck, and unlike men, there was no relationship between changes in leg fluid volume and either ΔNC or apnea-hypopnea index. These findings suggest a differing relationship between overnight fluid shift from the legs and severity of obstructive sleep apnea in women than in men with heart failure.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Probability of obstructive sleep apnea in male patients with systolic heart failure and some related factors

Background and Purpose: Sleep breathing disorders have a negative impact on the illness outcome and quality of life in patients with heart failure. This study was conducted to investigate the probability of obstructive sleep apnea in men with heart failure and some related factors. Method: This was a cross-sectional study conducted on 100 male patients with systolic heart failure selected throu...

متن کامل

Fluid Shifts in Heart Failure Might Cause Sleep Apnea Nocturnal Rostral Fluid Shift: A Unifying Concept for the Pathogenesis of Obstructive and Central Sleep Apnea in Men

Methods: 57 men with stable HF, NYHA class I to III, and ejection fraction (EF) ≤45 were studied. Leg fluid volume (LFV) was measured by bioelectric impedance; right calf and neck circumference were measured (with lines drawn to ensure consistency) before and after sleep. Patients with predominant OSA (≥ 50% obstructive events) and apnea-hypopnea index (AHI) ≥15 were offered continuous positive...

متن کامل

Rostral overnight fluid shift in end-stage renal disease: relationship with obstructive sleep apnea.

BACKGROUND In both healthy male subjects and men with heart failure, the severity of obstructive sleep apnea (OSA) is related to the amount of fluid displaced from their legs into the neck overnight. Whether overnight rostral fluid shift contributes to the pathogenesis of OSA in patients with end-stage renal disease (ESRD) is unknown. We hypothesized that the change in neck circumference (NC) a...

متن کامل

Heart Failure Nocturnal Rostral Fluid Shift A Unifying Concept for the Pathogenesis of Obstructive and Central Sleep Apnea in Men With Heart Failure

Background—Obstructive sleep apnea (OSA) and central sleep apnea are common in patients with heart failure. We hypothesized that in such patients, severity of OSA is related to overnight rostral leg fluid displacement and increase in neck circumference, severity of central sleep apnea is related to overnight rostral fluid displacement and to sleep PCO2, and continuous positive airway pressure a...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Circulation. Heart failure

دوره 5 4  شماره 

صفحات  -

تاریخ انتشار 2012