Pacing-Induced Alterations in Left Ventricular Mechanical Properties: Effect of Pacing Sites

The normal electrical cardiac activation sequence is required for optimal left ventricular (LV) contraction and efficient pump function. Pacing that is conducted at virtually any ventricular site disturbs the natural activation pattern and ventricular contraction because the applied impulse travels slowly through the myocardium rather than through the rapidly conducting His-Purkinje system. This results in prolonged QRS durations that resemble left bundle branch block and lead to ven-tricular dyssynchrony. Unfavorable effects of right ventricular (RV) pacing include ventricular remodeling, dilation, elevated diastolic filling pressure, increased functional mitral regurgi-tation, myocardial perfusion defects, and reduced LV ejection fraction. Of all ventricular sites, the RV apex seems to be the most hemodynamically unfavorable, but there is limited information regarding the effects of alternative pacing sites on LV mechanical properties. 2)3) In this issue of the Journal, Cho et al. 4) report the results of a prospective, multicenter study designed to assess the impacts of different RV pacing sites on LV dyssynchrony and adverse changes in global longitudinal LV contraction. They failed to demonstrate any differences in mechanical dyssynchrony parameters among the groups of different pacing sites, although the electrical dyssynchrony parameter was significanly different. However, patients with RV septal pacing showed better LV longitudinal systolic movement than those with RV apical pacing. Prinzen et al. 5) described nonuniformity of myocardial fiber strain during RV pacing using sonomicrometry in a dog model. Interestingly, in early-activated LV areas the amount of shortening was lower than in remote areas, resulting in decreases in net LV strain pattern during RV pacing. 5) Non-physiologic pacing sites such as the RV apex have been shown to decrease the contractile state of normal myocardium due to abnormal electrical propagation. Previous studies demonstrated histopathologic abnormalities in paced patients. Karpa-wich et al. 6) demonstrated increases in histopathological alterations in patient biopsy samples following pacing, including myofiber variation, fibrosis, fat deposition, sclerosis, and mito-chondrial morphological changes. These findings indicate that chronic RV apical pacing may adversely alter myocellular growth at the cellular and subcellular levels. Therefore, the observations of LV global longitudinal contraction by Cho et al. 4) add to the growing body of evidence that RV apical pacing increases the risk of LV dysfunction and heart failure. Although several studies have investigated the effects of pacing from alternative RV sites other than the apex, the results of studies examining eletromechanical dyssynchrony are conflicting. Flevari et al. 7) and Cano et al. 8) …