IMPORTANCE OF CHROMOSOME 8 GAIN AND c-myc GENE AMPLIFICATION IN HIGH GRADE PROSTATE CANCER
نویسندگان
چکیده
Son zamanlarda yapılan sitogenetik ve moleküler genetik çalışmalarla, 8q24’de lokalize olup özellikle ilerlemiş ve rekürrent prostat kanserlerinde amplifiye olan c-myc geni tanımlanmıştır. Bu çalışmada amacımız, prostat karsinogenezinde kromozom 8 kazancı ve c-myc’nin rolünü tanımlamak ve prostatik intraepitelial neoplazi (PIN) ve prostat kanseri arasındaki genetik ilişkiyi değerlendirmektir. 9 adenokarsinom, 6 PIN ve 15 benign prostatik hiperplazi (BPH)olmak üzere toplam 30 örnek Fluoresans in situ Hibridizasyon (FISH)’le değerlendirildi. Adenokarsinomların %88.8’inde tanımlanan kromozom 8 kazancı metastatik prostat kanseriyle beraberlik göstermektedir. PIN ve karsinomada en sık görülen anomali kromozom 8 kazancıdır ve bu anomalinin varlığı yüksek Gleason skoruyla beraberlik göstermektedir. C-myc geninin aşırı ekspresyonunda temel mekanizmanın amplifikasyon olmayabileceğine inanmaktayız. Bulgularımız c-myc gen ekspresyonunda temel mekanizmanın kromozom 8’in basit kazancı veya 8q’nun kazancından kaynaklanabileceğini göstermektedir. Sonuçlarımız PIN’nin karsinomanın prekürsörü olduğunu söyleyen diğer yazarların bulgularıyla tutarlıdır.
منابع مشابه
Clinical significance of alterations of chromosome 8 in high-grade, advanced, nonmetastatic prostate carcinoma.
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