Increased glycolytic metabolism in cardiac hypertrophy and congestive failure.

BISHOP, SANFORD P., AND RUTH A. ,~LTSCHULD. hcreased gi’ycdytic metubolism in cardiac hypertrophy and congestive fniluw. Am. J. Physiol. 218(I): 153-159. 1970.-Lactate dehydrogenase isozymes and potential for glycolytic metabolism in vitro were studied in right and left ventricles of 11 dogs with experimental right ventricular hypertrophy (RVH) and congestive heart failure (CHF), 8 dogs with acquired RVH and CHF due to DiroJilaria immitis, and 13 controls, Disc gel electrophoresis revealed that muscle-type (anaerobic) lactate dehydrogenase (M-LDH) was significantly increased in the hypertrophied right ventricles, and there was a lesser, but significant, increase of M-LDH in the left ventricle. Lactate production was significantly increased after Wmin anaerobic incubation of hypertrophied right ventricular homogenates compared to control right ventricular homogenates. Left ventricular homogenates from the D. z’mmitG group produced more lactate than control group left ventricles, Lactate production by left ventricles from dogs with experimentally produced RVH and CHF was not significantly different from control values. Glucose utilization by anaerobic homogenates was increased for both ventricles in the D. immitis group. These findings are interpreted as evidence for increased potential of the glycolytic pathways for energy production in the hypertrophied failing myocardium.