A Fatal Case of Ceftriaxone-Induced Autoimmune Hemolytic Anemia
نویسنده
چکیده
Hospital Physician July/August 2009 21 Ceftriaxone-induced autoimmune hemolytic anemia (AIHA) is an immune-mediated phenomenon caused by ceftriaxone, leading to the destruction of red blood cells (RBCs) and secondary anemia. Approximately 30 years ago, methyldopa and penicillin were the 2 medications most commonly associated with drug-induced AIHA. Currently, most cases of drug-induced AIHA are attributed to secondand third-generation cephalosporins, most commonly cefotetan and ceftriaxone. Although cefotetan-induced AIHA is more common, ceftriaxone-induced AIHA has been associated with higher fatality rates, with over 50% of reported fatalities caused by cephalosporininduced AIHA specifically attributed to ceftriaxone.1–5 This article reports the case of a man who was diagnosed with ceftriaxone-induced AIHA that proved to be fatal. A review of ceftriaxone-induced AIHA is also provided.
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Ceftriaxone-Induced Hemolytic Anemia in a Jehovah’s Witness
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