Early T 4 / T 8 - Ratio Shifts and Acute Gvhd
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چکیده
Acute graft-versus-host disease (GVHD). a major complication of allogeneic bone marrow transplantation (BMT). is probably mediated by T lymphocytes present in the marrow graft. In this study. the repopulation of the peripheral blood with T4 and T8 T cells was investigated during the period preceding the occurrence of acute GVHD. Twentyfour allogeneic and 1 1 autologous BMT recipients were monitored from day 4 post-BMT onward by the use of monoclonal antibodies. indirect immunofluorescence, and flow cytometry. The recipients of allogeneic transplants received methotrexate as GVHD prophylaxis. Similar recovery patterns for T4 and T8 T cells were found following autologous and allogeneic BMT. However. lymphoid repopulation occurred at a clearly faster rate after autologous BMT. T4 T cells were the first to reappear in
منابع مشابه
Early T 4 / T 8 - Ratio Shifts and Acute
Acute graft-versus-host disease (GVHD). a major complication of allogeneic bone marrow transplantation (BMT). is probably mediated by T lymphocytes present in the marrow graft. In this study. the repopulation of the peripheral blood with T4 and T8 T cells was investigated during the period preceding the occurrence of acute GVHD. Twentyfour allogeneic and 1 1 autologous BMT recipients were monit...
متن کاملEarly T 4 / T 8 - Ratio Shifts
Acute graft-versus-host disease (GVHD). a major complication of allogeneic bone marrow transplantation (BMT). is probably mediated by T lymphocytes present in the marrow graft. In this study. the repopulation of the peripheral blood with T4 and T8 T cells was investigated during the period preceding the occurrence of acute GVHD. Twentyfour allogeneic and 1 1 autologous BMT recipients were monit...
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Background : Graft versus host disease (GVHD) is among major complications of allogeneic hematopoietic stem cells transplantation, and also is an important factor affecting the outcome of transplantation. An increased incidence of GVHD has been suggested following allogeneic peripheral blood stem cells (PBSC) transplantation, however, how this affects survival is not yet well clear. In this stu...
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We have recently made the paradoxical observation that a single injection of recombinant murine interleukin-12 (IL-12) on the day of bone marrow transplantation (BMT) inhibits graft-versus-host disease (GVHD) in lethally irradiated mice receiving fully major histocompatability complex (MHC)-mismatched bone marrow and spleen cells. We have now examined the mechanism of this effect of IL-12 on ac...
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Graft-versus-host disease (GVHD) remains the major complication after allogeneic bone marrow transplantation (BMT). The process whereby acute GVHD mediated by alloreactive donor T cells transitions into chronic GVHD, which is characterized by prominent features of auto-immunity, has long been unresolved. In this study, we demonstrate that GVHD-associated autoimmunity and, by extension, chronic ...
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