STIM1 for stimulation of phagocyte NADPH oxidase.
نویسنده
چکیده
In this issue of Blood, Zhang et al show that mice lacking the stromal-interacting molecule 1 (STIM1) gene in bone marrow cells are more susceptible to bacterial infection but are resistant to ischemia/reperfusion injury because of defective activation of phagocyte nicotinamide adenine dinucleotide phosphate (NADPH) oxidase.
منابع مشابه
Functional Reconstitution of the Phagocyte NADPH Oxidase by Transfection of Its Multiple Components in a Heterologous System
The phagocyte NADPH oxidase system, as previously defined by cell-free reconstitution, is comprised of five essential components, three of which are produced during late phagocytic differentiation-namely, two cytosolic proteins, p47and p67-phox-and the large subunit of cytochrome bSs8, gp91-phox. To confirm that these are the only phagocyte-specific components necessary for oxidase activity in ...
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ورودعنوان ژورنال:
- Blood
دوره 123 14 شماره
صفحات -
تاریخ انتشار 2014