Controversy: HLA Antibodies Responsible for Fetal/Neonatal Alloimmune Thrombocytopenia – an Update
نویسنده
چکیده
This review focuses on reports on fetal/neonatal alloimmune thrombocytopenia (FNAITP) – presumably due to alloimmunization to HLA antigens – published during the last 6 years. Platelets express HLA class I antigens, and HLA antibodies are known to adversely affect the success of platelet transfusions. Likewise, it is conceivable that HLA antigens can serve as targets leading to HLA antibody-induced FNAITP. A very comprehensive review on the subject has been published by Taaning in 2000 [1]. After carefully discussing the pros and cons, the author concluded that evidence that HLA antibodies may induce FNAITP is rather weak. Since this publication only three new papers have been dealing with neonatal thrombocytopenia which might be due to maternal alloantibodies with HLA class I specificity [2–4]. Controversy: HLA Antibodies Responsible for Fetal/Neonatal Alloimmune Thrombocytopenia – an Update
منابع مشابه
Fetal and neonatal alloimmune thrombocytopenia.
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is one of the major causes of both severe thrombocytopenia and intracranial haemorrhage in fetuses and term neonates. The incidence of FNAIT is estimated to be one in 1000-2000 births. FNAIT is caused by maternal immunoglobulin G alloantibodies, which cross the placenta and are directed against human platelet antigens (HPA) on fetal platele...
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