Synthesis of some thienopyrimidine derivatives.
نویسندگان
چکیده
Thioxothienopyrimidinones, alkylthio- and arylalkylthiothienopyrimidinones, thienopyrimidinones, thienopyrimidines a thienopyrimidinedione and a thienotriazolo-pyrimidinone were prepared from 2-amino-3-carboethoxy-4,5-disubstituted thiophenes and 2-amino-3-cyano-4,5-disubstituted thiophenes via reactions with different reagents.
منابع مشابه
Synthesis, Characterization, Antimicrobial and Anti-Inflammatory activities of novel N-(Sugar Pyranosyl) Thienopyrimidine 4-Amine derivatives
A novel N-(sugar pyranosyl) thienopyrimidine 4-amine derivatives were synthesized. These derivatives were identified on the basis of melting point range, Rf values, IR and 1H NMR spectral analysis. The derivatives were screened for antimicrobial and anti-inflammatory activities. The derivatives exhibited significant to moderate antimicrobial and anti-inflammatory activities.
متن کاملScreening for antidepressant, sedative and analgesic activities of novel fused thiophene derivatives.
This study was aimed at the synthesis of fused benzothiophene derivatives containing heterocyclic moiety. The reaction of the tetrahydrobenzo[b]thiophene derivatives 1a,b with ethoxycarbonylisothiocyanate afforded the thiourea derivatives 2a,b. Cyclization of the latter products gave the annulated benzo[b]thienopyrimidine derivatives 3a,b. Compounds 2a,b and 3a underwent a series of heterocycli...
متن کاملSynthesis and antimicrobial activity of new substituted thienopyrimidines, their tetrazolyl and sugar derivatives.
A series of substituted 5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidine-4-one derivatives were newly synthesized starting from 5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidine-4-one derivatives (1). Furthermore, their derived tetrazolyl as well as the N-substituted derivatives were also prepared. The antimicrobial activity of the prepared compounds against Escherichia coli, Bacil...
متن کاملSynthesis and antimicrobial evaluation of some new thienopyrimidine derivatives.
Reaction of heteroaromatic o-aminonitrile with ethyl N-[bis(methylthio)methylene]amino acetate resulted in annelation of a thieno[3,2-e]imidazo[1,2-c]pyrimidine moiety in a one step process. [1,2,4]Triazolo[4,3-c]thieno- [3,2-e]pyrimidine derivatives were prepared by initial treatment of o-aminonitrile with carbon disulfide, followed by methylation with methyl iodide and subsequent reaction wit...
متن کاملSynthesis and Antitumor Activity of Novel Thienopyrimidine Derivatives Containing Thiosemicarbazide Moiety
The present study focused on synthesizing a series of novel derivatives of 4-aryl-1-[2-(3-benzyl-4oxo(3H)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-2-ylsulphanyl) acetyl] thiosemicarbazide 5a-d and evaluating their antitumor activity. The structure of the synthesized compounds has been elucidated on the basis of elemental analyses and spectroscopic methods (IR, 1H-NMR, 13C-NMR and MS). T...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Molecules
دوره 11 7 شماره
صفحات -
تاریخ انتشار 2006