Should zygote intrafallopian transfer be offered to all patients with unexplained repeated in-vitro fertilization cycle failures?
نویسندگان
چکیده
BACKGROUND One of the suggest strategy for patients with repeated implantation failure (RIF) is zygote intrafallopian transfer (ZIFT). However, no data exist regarding to the issue of when and under which circumstances should ZIFT be offered to patients with RIF? We therefore aimed to examine whether repeated implantation failure (RIF) patients characteristics or their previous controlled ovarian hyperstimulation (COH) variables may differentiate between those who will conceive following a ZIFT cycle and those who will not. METHODS Forty seven consecutive women admitted to our IVF unit during a 7 year period, who underwent ZIFT for RIF, were included. Ovarian stimulation characteristics, number of oocytes retrieved and number and quality of zygotes/embryos transferred were assessed and compared between the ZIFT cycle and the previous IVF/ICSI cycle and between those who conceived following the ZIFT cycle and those who did not. RESULTS Twelve clinical pregnancies (clinical pregnancy rate- 25.5%) were recorded following the ZIFT cycle. Those who benefit from ZIFT were young patients (≤31 yrs), who underwent ≤6 cycle attempts, yielding over eight 2PN embryos with low (≤0.4) ratio of number of top-quality embryos to total 2PN embryos. Moreover, in those destined for a ZIFT cycle, only those with >7 2PN embryo should undergo a transfer of at least five 2PN embryos. CONCLUSIONS Further large prospective studies are needed to identify the specific characteristics of RIF women who may benefit from ZIFT.
منابع مشابه
Zygote Intrafallopian Transfer
Zygote intrafallopian transfer (ZIFT) is an assisted reproductive technology [5] (ART) first used in 1986 to help those who are infertile conceive a child. ZIFT is a hybrid technique derived from a combination of in vitro [6] fertilization [7] (IVF) and gamete intrafallopian transfer (GIFT) procedures. Despite a relatively high success rate close to that of IVF, it is not as common as its paren...
متن کاملZygote Intrafallopian Transfer
Zygote intrafallopian transfer (ZIFT) is an assisted reproductive technology [5] (ART) first used in 1986 to help those who are infertile conceive a child. ZIFT is a hybrid technique derived from a combination of in vitro [6] fertilization [7] (IVF) and gamete intrafallopian transfer (GIFT) procedures. Despite a relatively high success rate close to that of IVF, it is not as common as its paren...
متن کاملAssisted Reproductive Technologies
Assisted reproductive technologies (ART) are a collection of different techniques designed to help those who are infertile achieve a successful pregnancy [4]. The most popular technology currently in use is in vitro [5] fertilization [6] (IVF), but others include gamete intrafallopian transfer (GIFT), zygote intrafallopian transfer [7] (ZIFT), intrauterine insemination (IUI), and intracytoplasm...
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Background: In spite of the great deal of research in assisted reproductive techniques, more than 80% of transferred embryos by IVF/ICSI methods fail to be implanted. The causes for repeated implantation failures (RIF) may be reduced endometrial receptivity or other various uterine pathologies, such as thin endometrium, altered expression of adhesive molecules or immunological factors; whereas ...
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