Once daily slow-release hydralazine in hypertension.

Hydralazine has been used for the treatment of hypertension since 1950 (Gross et al., 1950), but only since the introduction of beta-adrenoceptor blocking agents has its use again become popular (Koch-Weser, 1976). Originally, hydralazine was given in four divided doses, but it has been shown to be equally effective and without increased side-effects when given by twice daily dosage (O'Malley e t al., 1975). In the present study, the antihypertensive effect of a slowrelease formulation of hydralazine given once daily was compared with conventional hydralazine (Apresoline) given twice daily in hypertensive patients being treated with oxprenolol. Compliance with both regimens was also compared.