Replication study of estrogen receptor 1 XbaI polymorphism in adolescent idiopathic scoliosis (AIS) Caucasian population
نویسندگان
چکیده
Background It has been suggested that XbaI single nucleotide polymorphism (SNP) (A/G rs934099) in estrogen receptor 1 (ESR1) may be associated with curve severity in Japanese AIS patients [1] and with both curve severity and predisposition for AIS in Chinese patients [2]. However, replication studies have not confirmed these findings [3]. The role of the XbaI ESR1 polymorphism rs9340799 in AIS has never been described in Caucasian AIS patients.
منابع مشابه
10th International Conference on Conservative Management of Spinal Deformities - SOSORT 2013 Annual Meeting.
Background: Central nervous system function is dependent upon neurotransmitters to properly integrate midbrain and cortical function. Central nervous system dysfunction is thought to be a primary driver of AIS progression. Purpose: The goal of this study was to observe and analyze any patterns of imbalance in neurotransmitter status in patients with AIS. Methods: The charts of 31 AIS patients f...
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INTRODUCTION XbaI single nucleotide polymorphism (SNP) (A/G rs934099) in estrogen receptor 1 gene (ESR1) was described to be associated with curve severity in Japanese idiopathic scoliosis (IS) patients and in Chinese patients with both curve severity and predisposition to IS. PvuII SNP (C/T rs2234693) of ESR1 was described to be associated with the occurrence of IS in the Chinese population; h...
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