Sorafenib for the treatment of solid malignancies: what about the cancer microenvironment?
نویسندگان
چکیده
License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php International Journal of Nanomedicine 2013:8 4043–4044 International Journal of Nanomedicine Dovepress
منابع مشابه
Targeting the Tumor Microenvironment: Focus on Angiogenesis
Tumorigenesis is a complex multistep process involving not only genetic and epigenetic changes in the tumor cell but also selective supportive conditions of the deregulated tumor microenvironment. One key compartment of the microenvironment is the vascular niche. The role of angiogenesis in solid tumors but also in hematologic malignancies is now well established. Research on angiogenesis in ge...
متن کاملThe Role of Exosomes in Myeloid and Lymphoid Blood Malignancies: A Systematic Review Article
Background and Aim: Blood malignancies, one of the most common cancers in the world, cause a large number of deaths each year. Many inherited and acquired factors are involved in the development of this disease. Exosomes are a very small model of cells that are secreted by most cells in the body under physiological and pathological conditions. On the other hand, they have found a special place ...
متن کاملبررسی بروز سرطان ثانویه پس از درمان بیماران مبتلا به لنفوم هوچکین در بیمارستان حضرت علیاصغر(ع)
Hodgkin’s disease is one of the most common childhood malignancies that with correct diagnosis and effective treatment is curable and without treatment is leading to death. The survival of patients with Hodgkin’s disease has dramatically improved over the past 30 years because of advances in treatment. However, concern for the risk of long tern complications has resulted in a number of tria...
متن کاملThe effect of nanomicelle curcumin, sorafenib, and combination of the two on the cyclin D1 gene expression of the hepatocellular carcinoma cell line (HUH7)
Objective(s): Hepatocellular carcinoma (HCC) is one of the most significant health condition around the world. As the only curative therapies, liver transplantation and surgical resection are the clinical treatments of HCC. Due to the systemic toxicity and severe side effects of these treatments, it is vital to establish new therapeutic approaches. The present study ai...
متن کاملSorafenib Dose Escalation is Not Uniformly Associated with Blood Pressure Elevations in Normotensive Patients with Advanced Malignancies
Hypertension after treatment with vascular endothelial growth factor (VEGF) receptor inhibitors is associated with superior treatment outcomes for advanced cancer patients. To determine whether increased sorafenib doses cause incremental increases in blood pressure (BP), we measured 12-h ambulatory BP in 41 normotensive advanced solid tumor patients in a randomized dose-escalation study. After ...
متن کامل