A reverse genetics approach to study feline infectious peritonitis.

نویسندگان

  • Gergely Tekes
  • Danica Spies
  • Barbara Bank-Wolf
  • Volker Thiel
  • Heinz-Jürgen Thiel
چکیده

Feline infectious peritonitis (FIP) is a lethal immunopathological disease caused by feline coronaviruses (FCoVs). Here, we describe a reverse genetics approach to study FIP by assessing the pathogenicity of recombinant type I and type II and chimeric type I/type II FCoVs. All recombinant FCoVs established productive infection in cats, and recombinant type II FCoV (strain 79-1146) induced FIP. Virus sequence analyses from FIP-diseased cats revealed that the 3c gene stop codon of strain 79-1146 has changed to restore a full-length open reading frame (ORF).

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عنوان ژورنال:
  • Journal of virology

دوره 86 12  شماره 

صفحات  -

تاریخ انتشار 2012