The fluorescence regulation mechanism of the paramagnetic metal in a biological HNO sensor.

نویسندگان

  • Wenjing Yang
  • Xuebo Chen
  • Huizhen Su
  • Weihai Fang
  • Yong Zhang
چکیده

Paramagnetic metals are frequently used to regulate fluorescence emissions in chemical and biological probes. Accurate quantum calculations offer the first regulation theory that quenching is through the competitive nonradiative decay of the mixed fluorophore/metal (3)ππ*/dd state isoenergetic to the fluorophore-localized (1)ππ* state.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

HNO/NO Conversion Mechanisms of Cu-Based HNO Probes with Implications for Cu,Zn-SOD

HNO has broad biological effects and pharmacological activities. Direct HNO probes for in vivo applications were recently reported, which are CuII-based complexes having fluorescence reporters with reaction to HNO resulting in CuI systems and the release of NO. Their coordination environments are similar to that in Cu,Zn-superoxide dismutase (SOD), which plays a significant role in cellular HNO...

متن کامل

Development of a Polyfunctional Dipodal Schiff Base: An Efficient Chelator and a Potential Zinc Sensor

A novel polyfunctional dipodal ligand, L = N,N'-bis[2-[(2-hydroxy-1-naphthyl)methyleneamino]ethyl]propanediamide (DOTA2HNAP) was developed and characterized through elemental and spectral analyses. The complexation behavior of the ligand was investigated with Co2+, Cu2+, and Zn2+ metal ions by potentiometric and spectrophotometric methods in H2O-D...

متن کامل

HNO Detection by Nanosized B12N12 Cage: A DFT/TDDFT Study

The interaction of a nitrosyl hydride (HNO) molecule with B12N12 nanocage was explored by means of density functional calculations. It was found that HNO prefers to be adsorbing on a boron atom of the cage with adsorption energy of -0.65 eV. This adsorption process significantly shifts the HOMO-LUMO gap (Eg) of the cage to lower energies, thereby reducing Eg of the cage from 6.84 to 2.45 eV. Ti...

متن کامل

An amine/imine functionalized microporous MOF as a new fluorescent probe exhibiting selective sensing of Fe3+ and Al3+ over mixed metal ions

Nowadays metal-organic frameworks with multiple luminescent centers are very fascinating as multifunctional luminescent material because of their luminescence properties, which could be systematically tuned by deliberate use of organic ligands and metal ions. In this research, we explored a microporous mixed-ligand MOF for highly selective and sensitive detection of metal ions. A two-fold inter...

متن کامل

A Fast and Selective Near-Infrared Fluorescent Sensor for Multicolor Imaging of Biological Nitroxyl (HNO)

The first near-infrared fluorescent turn-on sensor for the detection of nitroxyl (HNO), the one-electron reduced form of nitric oxide (NO), is reported. The new copper-based probe, CuDHX1, contains a dihydroxanthene (DHX) fluorophore and a cyclam derivative as a Cu(II) binding site. Upon reaction with HNO, CuDHX1 displays a five-fold fluorescence turn-on in cuvettes and is selective for HNO ove...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Chemical communications

دوره 51 47  شماره 

صفحات  -

تاریخ انتشار 2015