Tinidazole in treatment of amoebic liver abscess in children.
نویسندگان
چکیده
Tinidazole as a single drug therapy given in a single dose daily for 5 or 3 days was put to rigorous test in malnourished children. Of 25 children with amoebic liver abscess, 23 were cured. The 2 remaining cases required surgical drainage followed by other amoebicides, one subsequently dying from complicating bronchopneumonia.
منابع مشابه
Children with Amoebic Liver Abscess
A combination of emetine hydrochloride with chloroquine yields better results than either drug alone in the treatment of amoebic liver abscess in adults (Wilmot, Powell, and Adams, 1959). A similar combination of dehydroemetine with chloroquine is equally satisfactory (Wilmot, Powell, MacLeod, and Elsdon-Dew, 1964; Powell, Wilmot, MacLeod, and Elsdon-Dew, 1967). Dehydroemetine is claimed to be ...
متن کاملMetronidazole and niridazole combined with dehydroemetine in treatment of children with amoebic liver abscess.
Metronidazole and niridazole combined with dehydroemetine in treatment of children with amoebic liver abscess. Metronidazole combined with dehydroemetine cured 13 of 15 children with amoebic liver abscess. An alternative combination of niridazole with dehydroemetine produced cure in 13 of 14 children. No relapses were observed. Electrocardiographic changes were noted in 2 of the first group and...
متن کاملEmetine hydrochloride and chloroquine in the treatment of children with amoebic liver abscess.
Although amoebic liver abscess is infrequent in children, the outcome is much less favourable than it is in adults. When treated with combined emetine hydrochloride, chloroquine, and aspiration, the prognosis is excellent in adults (Wilmot, 1962), this regime being more successful than treatment with a single drug (Wilmot, Powell, and Adams, 1959; Wilmot, Powell, MacLeod, and Elsdon-Dew, 1964)....
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The excellent results obtained in this trial indicate that tinidazole is a drug worthy of extensive evaluation in the treatment of amoebiasis, as three single daily doses is a simple form of treatment. The drug was well tolerated and free from any toxic effects.
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Tinidazole (1-[2-(ethylsulfonyl)ethyl]-2-methyl-5-nitroimidazole) was first introduced into clinical medicine in 1967 and has been used in Europe, Australia, Asia and in a number of developing countries for decades. It was approved by the FDA for the treatment of protozoal infections like trichomoniasis, giardiasis, intestinal amoebiasis, amoebic liver abscess. It is also very effective for bac...
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ورودعنوان ژورنال:
- Archives of disease in childhood
دوره 52 5 شماره
صفحات -
تاریخ انتشار 1977