GH/IGF-I axis regulation of cardiovascular and neuronal gene expression and function
نویسنده
چکیده
.................................................................................................................................... 3 Populärvetenskaplig sammanfattning på svenska ................................................................ 4 Table of contents ...................................................................................................................... 5 List of publications ................................................................................................................... 9 Abbreviations.......................................................................................................................... 11 Background ............................................................................................................................. 13 Growth hormone (GH) and insulin-like growth factor I (IGF-I) axis ........................................ 13 Growth hormone secretagogues (GHS)...................................................................................... 13 The cardiovascular system ......................................................................................................... 14 Peripheral resistance ............................................................................................................... 14 GH/IGF-I and the cardiovascular system ............................................................................... 15 The central nervous system ........................................................................................................ 15 Adult neurogenesis ................................................................................................................. 16 Radiation and neurogenesis .................................................................................................... 17 GH/IGF-I, GHS and neurogenesis .......................................................................................... 17 Aims of the thesis .................................................................................................................... 19 Methodological aspects .......................................................................................................... 21 Animal models............................................................................................................................ 21 Anesthesia .................................................................................................................... 21 Hypophysectomy and hormonal replacement.............................................................. 22 Hormone treatment ...................................................................................................... 22 Blood pressure ............................................................................................................. 22 Cranial Irradiation ........................................................................................................ 23 Place learning ............................................................................................................... 23 Intellicage..................................................................................................................... 24
منابع مشابه
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We have previously reported (Bauer MK, Breier BH, Bloomfield FH, Jensen EC, Gluckman PD, and Harding JE. J Endocrinol 177: 83-92, 2003) that a chronic pulsatile infusion of growth hormone (GH) to intrauterine growth-restricted (IUGR) ovine fetuses increased fetal circulating IGF-I levels without increasing fetal growth. We hypothesized a cortisol-induced upregulation of fetal hepatic GH recepto...
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