Hyperlipidemia as an Instigator of Inflammation: Inaugurating New Approaches to Vascular Prevention

F or much of the past quarter century, 2 broadly competing scientific views have dominated translational research concerning atherogenesis and atherothrombosis. On one side has been a predominantly lipid-centric view in which lowdensity lipoprotein (LDL) cholesterol, a proven causal factor in atherosclerosis, has been viewed as the major if not sole determinant of disease initiation and progression. Pioneering descriptions of the role played by the LDL receptor in human disease and the remarkable success of statin therapy provide