Prognostic Scoring System cytogenetic classification on outcome after allogeneic stem cell transplantation in patients with myelodysplastic syndromes or secondary acute myeloid leukemia who were reported to the European Society for Blood and Marrow Transplantation

netic risk classification entered the revised IPSS (IPSS-R) scoring system for patients with MDS, which was renewed in 2012 accordingly. The impact of the revised IPSS-R for MDS patients undergoing SCT was analyzed in one single center study, and more recently in a national multicenter study. These studies have shown that the novel classification has greater discriminating power for OS and relapse after SCT than the old IPSS classification. In contrast to the latter studies, we focused only on cytogenetic information of the novel 5-group IPSS-R classification to evaluate the outcome of MDS and sAML patients after SCT in an analysis based on a large cohort from the European Society for Blood and Marrow Transplantation (EBMT) database. The analysis was performed using the latest available karyotype before transplantation, restricted to measurements within one year before SCT. In addition to previous findings which also focus on IPSS-R cytogenetics and SCT, we show that poor and very poor risk cytogenetics, within the IPSS-R-cytogenetic risk categories, are strong predictors of poor outcome after transplantation, also when other risk factors are considered simultaneously. Furthermore, the presence of a monosomal karyotype (MK) has an additional impact on RFS and OS, but only in the poor risk group and not in the very poor risk cytogenetics group of patients.