MRI Evaluation of a Peptide-Coated Nanoparticle as a Potential Therapy Against Preclinical Brain Metastatic Breast Cancer
نویسندگان
چکیده
MRI Evaluation of a Peptide-Coated Nanoparticle as a Potential Therapy Against Preclinical Brain Metastatic Breast Cancer Amanda M Hamilton, Sallouha Aidoudi-Ahmed, Venkata R Kotamraju, Shweta Sharma, Paula J Foster, Kazuki N Sugahara, Erkki Ruoslahti, and Brian K Rutt Robarts Research Institute, London, Ontario, Canada, Sanford-Burnham Medical Research Institute, California, United States, Stanford University, California, United States
منابع مشابه
ارزیابی اثر نانوذرات داستیل کیتین بر میزان بیان ژن VEGF در مدل متاستاتیک سرطان سینه
Background and purpose: Breast cancer is one of the leading causes of death in women around the world. Conventional treatments use cytotoxic drugs which have high levels of side effects. Today, researchers are more interested in developing novel drugs that have lower side effects and maximum efficiency. Deacetylchitin is a biodegradable and biocompatible polymer. The goal of this research was t...
متن کاملIn Vitro Cytotoxic Activity of a Lactococcus lactis Antimicrobial Peptide Against Breast Cancer Cells
Background: Nisin, an effective natural food preservative, is an antimicrobial peptide produced by Lactococcus lactis. Although it has been mainly studied and developed as a potential alternative for antibiotics, other pharmacological effects of the nisin including cytotoxic and anti-tumor activity have been attracted many attentions.Objectives: Here, we ...
متن کاملPreclinical Evaluation of Oncolytic Δγ134.5 Herpes Simplex Virus Expressing Interleukin-12 for Therapy of Breast Cancer Brain Metastases
The metastasis of breast cancer to the brain and central nervous system (CNS) is a problem of increasing importance. As improving treatments continue to extend patient survival, the incidence of CNS metastases from breast cancer is on the rise. New treatments are needed, as current treatments are limited by deleterious side effects and are generally palliative. We have previously described an o...
متن کاملA Novel Biocompatible Nanoprobe Based on Lipoproteins for Breast Cancer Cell Imaging
Objective(s): Contrast-enhanced magnetic resonance imaging (MRI) of breast cancer provides valuable data on the disease state of patients. Biocompatible nanoprobes are expected to play a pivotal role in medical diagnosis in the future owing to their prominent advantages. The present study aimed to introduce a novel biocompatible nanoprobe based on lipoproteins for breast cancer cell imaging.<br...
متن کاملDesign, synthesis and biological evaluation of Ciprofloxacin- peptide conjugates as anticancer agents
Cancer has emerged as a leading cause of death throughout the world. Peptides are a novel class of anticancer agents that can specifically target cancer cells with low toxicity to normal tissues and thus, offer new opportunities for future cancer treatment. On the other hand, Ciprofloxacin, an antibiotic, also known to its anticancer property for enabling cell cycle arrest and creating double s...
متن کامل