Danazol enhances Fas-mediated apoptosis in human endometrial epithelial cells within normal physiology.

P-156: Survey of In Vitro Effect of Resveratrol on Apoptosis of Human Endometrial Epithelial Cells

Background: In apoptosis is physiological cell death which eliminates injured and old cells. Any disruption in apoptosis, leads to disease. Resveratrol is a natural polyphenol with estrogen-like, antioxidant and antiinflammatory properties; also it showed cell prolifratory and inhibitory effect. The aim of present study was to determine resveratrol effect on apoptosis of human endometrial epith...

Caspase cascade of Fas-mediated apoptosis in human normal endometrium and endometrial carcinoma cells.

Human endometrial epithelial cells undergo apoptosis immediately before the menstrual period. Apoptotic signalling was analysed using human endometrial tissue and a human endometrial carcinoma cell line (HHUA). Activity levels of caspase-3, -8, and -9 were elevated in human endometrium during the late secretory phase and in HHUA cells incubated with an anti-Fas monoclonal antibody (mAb). Fas-me...

Leptin regulates the proliferation and apoptosis of human endometrial epithelial cells.

The biological functions of leptin in the human endometrial epithelium were investigated using the human endometrial epithelial cell line, HHUA. Specifically, the effects of leptin on the proliferation and apoptosis of HHUA cells induced by treatment with anti-Fas IgM or anticancer drugs were examined. RT-PCR detected the expression of four leptin receptor isoform mRNAs in the cells and flow cy...

Sildenafil Effect on Nitric Oxide Secretion by Normal Human Endometrial Epithelial Cells Cultured In vitro

Cytokine regulation of human intestinal primary epithelial cell susceptibility to Fas-mediated apoptosis.

The regulatory mechanisms of nontransformed intestinal epithelial cell apoptosis have not been thoroughly investigated. We determined the susceptibility and mechanism of Fas-mediated apoptosis in nontransformed human intestinal epithelial cells (HIPEC) in the presence and absence of inflammatory cytokines. Despite ample expression of Fas, HIPEC were relatively insensitive to Fas-mediated apopto...