Effects of 20-HETE and 19(S)-HETE on rabbit proximal straight tubule volume transport.

20-HETE or EETs: which arachidonic acid metabolite regulates proximal tubule transporters and contributes to pressure natriuresis?

A MAJOR FUNCTION OF THE KIDNEY is to maintain body fluid and electrolyte homeostasis. Pressure natriuresis is a renal phenomenon that contributes to the long-term regulation of fluid and electrolyte balance and ultimately arterial blood pressure control. The basic phenomenon is that the kidney increases sodium excretion in response to an increase in renal perfusion pressure. A number of studies...

20-HETE and the kidney: resolution of old problems and new beginnings.

The protean properties of 20-hydroxyeicosatetraenoic acid (HETE), vasoactivity, mitogenicity, and modulation of transport in key nephron segments, serve as the basis for the essential roles of 20-HETE in the regulation of the renal circulation and electrolyte excretion and as a second messenger for endothelin-1 and mediator of selective renal effects of ANG II. Renal autoregulation and tubular ...

AREGU September 46/3

McGiff, John C., and John Quilley. 20-HETE and the kidney: resolution of old problems and new beginnings. Am. J. Physiol. 277 (Regulatory Integrative Comp. Physiol. 46): R607–R623, 1999.—The protean properties of 20-hydroxyeicosatetraenoic acid (HETE), vasoactivity, mitogenicity, and modulation of transport in key nephron segments, serve as the basis for the essential roles of 20-HETE in the re...

On the other hand 20-HETE also inhibits NaK-ATPase activity in the proximal tubule and TALH, and impaired renal production of 20-HETE is associated with Na retention and the development of hypertension in Dahl salt-sensitive rats

Down-regulation of 20-HETE synthesis and signaling inhibits renal adenocarcinoma cell proliferation and tumor growth.

BACKGROUND We examined the ability of inhibitors of the synthesis or actions of 20-HETE, metabolite of arachidonic acid, to inhibit proliferation of human renal carcinoma cell lines. MATERIALS AND METHODS 786-O and 769-P cells were exposed to either 10 microM HET0016 (selective inhibitor of 20-HETE synthesis), 10 microM WIT002 (20-HETE antagonist), or vehicle. Subsequently, we assessed the ef...