Studies on the synthesis of new derivatives of 8-aryl-4-imino-2,3,7,8-tetrahydro-imidazo [2,1-c][1,2,4] triazin-3 (6H)-one with an expected biological activity.
نویسنده
چکیده
Reaction of 1-aryl-2-hydrazono-imidazolidines with ethyl oxamate furnished novel derivatives of imidazo [2,1-c][1,2,4] triazine.
منابع مشابه
Design, Synthesis and Biological Evaluation of New Imidazo[2,1-b]Thiazole Derivatives as Selective COX-2 Inhibitors
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A new series of imidazo[2,1-b]thiazole analogs containing a methyl sulfonyl COX-2 pharmacophore was synthesized and evaluated for their COX-2 inhibitory activity. According to in-vitro COX-1/COX-2 inhibition data, all compounds (6a-g) were selective inhibitors of COX-2 isoenzyme with IC50 values in the highly potent 0.08-0.16 mM range. These results indicated that both potency and selectivity o...
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1,3-Diphenylbenzo[e][1,2,4]triazin-7(1H)-one, the oxidation product of 1,3-diphenyl-1,4-dihydro-1,2,4-benzotriazin-4-yl (Blatter's radical), reacts with N'-arylbenzamidines in PhMe at ca. 100 °C in the presence of N,N-diisopropylethylamine (Hünig's base) (1 equiv.) to give N'-aryl-N-(1,7-dihydro-7-oxo-1,3-diphenylbenzo[e][1,2,4]triazin-6-yl)benzimidamides in 49-95% yield. In neat AcOH heated at...
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ورودعنوان ژورنال:
- Acta poloniae pharmaceutica
دوره 62 3 شماره
صفحات -
تاریخ انتشار 2005