Alkylation of Theobromine: Preparation of Isopropyl and sec-butyl- theobromines using N, N-dimethylformamide as Solvent
نویسنده
چکیده
N-isopropyltheobromine and N-sec-butyltheobromine were synthesized via nucleophilic substitution reaction by reacting theobromine and two kind of alkyl bromide derivatives, i.e. isopropyl bromide and sec-butyl bromide using N, Ndimethylformamide (DMF) as a solvent. Yields (N-isopropyltheobromine = 7.70%; N-sec-butyltheobromine = 5.89%) were slightly less than the previous synthesis which used ethanol-water (10%) as a solvent.
منابع مشابه
Volatile Constituents of the Seed Kernel and Leaf of Moringa peregrina (Forssk.) Fiori, Agricolt. Cultivated in Chabahar (Iran)
Volatile constituents of the seed kernel and leaf of cultivated Moringa peregrina (Forssk.) Fiori, Agricolt collected after hydrolysis were analyzed by GC and GC/MS. Five glucosinolate degradation products which constituted almost the whole isolated oil of the seed kernel were identified to be: isobutyl isothiocyanate (94.0%), isopropyl isothiocyanate (4.9%), sec-butyl isothiocy...
متن کاملAmmonium salts as economical and eco-friendly N-sources applied to green, simple and scale-up synthesis of trialkyl amines in water
We have introduced a selective synthesis of tertiary amines using alkyl halide and ammonium salts as the amine sources in water. This green process has outstanding superiorities, such as being eco-friendly, possessing ammonium salts, and using water as a green solvent in the absence of organic ligands or catalysts. It is worth mentioning that the presence of t-Butyl alcohol and potassi...
متن کاملN3-alkylation during formation of quinazolin-4-ones from condensation of anthranilamides and orthoamides.
Dimethylformamide dimethylacetal (DMFDMA) is widely used as a source of electrophilic one-carbon units at the formate oxidation level; however, electrophilic methylation with this reagent is previously unreported. Reaction of anthranilamide with DMFDMA at 150 °C for short periods gives mainly quinazolin-4-one. However, prolonged reaction with dimethylformamide di(primary-alkyl)acetals leads to ...
متن کاملLignin peroxidase oxidation of aromatic compounds in systems containing organic solvents.
Lignin peroxidase from Phanerochaete chrysosporium was used to study the oxidation of aromatic compounds, including polycyclic aromatic hydrocarbons and heterocyclic compounds, that are models of moieties of asphaltene molecules. The oxidations were done in systems containing water-miscible organic solvents, including methanol, isopropanol, N, N-dimethylformamide, acetonitrile, and tetrahydrofu...
متن کاملSolvent effect modelling of isocyanuric products synthesis by chemometric methods
Chemometric tools were used to generate the modelling of solvent effects on the N-alkylation of an isocyanuric acid salt. The method proceeded from a central composite design applied on the Carlson solvent classification using principal components analysis. The selectivity of the reaction was studied from the production of different substituted isocyanuric derivatives. Response graphs were obta...
متن کامل