Tris(p-aminophenyl)carbonium pamoate and tumor induction in albino rats.

Tnis(p-aminophenyl)carbonium pamoate (2 lots) was administered as drug-diet for an 18-month period to male and female albino rats (Holtzman source) . Both lots of compound were prepared from the chloride salt, one from an approximately 98.6 % pure sample, and the other from a highly purified and apparently homogenous sample. There was a marked increase in total tumor incidence in the treated female rats (83 and 84 %) compared with the control females (21 %), but not in the treated male rats (12 and 15 %) compared with the control males (17 %). Tumors of the skin sebaceous glands and of the mammary glands were increased in incidence, and tumors were induced in the small intestine, in the subcutaneous tissue, and in the auditory canal gland. Induction times of the tumors were shortened, especially in females, compared with the control animals.