Comparison by meta-analysis of drug-eluting stents and bare metal stents for saphenous vein graft intervention.
نویسندگان
چکیده
This meta-analysis was undertaken to assess the efficacy and safety of drug-eluting stents (DESs) compared to bare metal stents (BMSs) in saphenous vein graft (SVG) interventions. DESs decrease the risk of target vessel revascularization in native coronary arteries compared to BMSs. The ideal treatment strategy in patients with SVG disease is unknown. A search of the published reports was conducted to identify studies that compared DESs and BMSs in SVG intervention with a minimum follow-up of 6 months. A total of 19 studies (2 randomized trials and 17 registries), including 3,420 patients who had undergone SVG intervention (DESs, n = 1,489 and BMS, n = 1,931), met the selection criteria. The mean length of follow-up was 20 + or - 12 months. Using the fixed effect model, target vessel revascularization was less frequently performed in patients who had undergone SVG intervention with a DES than with a BMS (odds ratio [OR] 0.59, 95% confidence interval [CI] 0.49 to 0.72). The incidence of myocardial infarction was lower in patients with a DES than in those with a BMS (OR 0.69, 95% CI 0.49 to 0.99). No differences were found in the risk of death (OR 0.78, 95% CI 0.59 to 1.02) or stent thrombosis (OR 0.41, 95% CI 0.15 to 1.11) between the 2 groups. In conclusion, these findings support the use of DESs in SVG lesions.
منابع مشابه
Clinical outcome of 2nd generation drug- eluting stents versus bare-metal stents in percutaneous intervention on vein grafts
2015 Background: Superiority of drug-eluting stents (DES) over bare-metal stents (BMS) for treatment of saphenous vein graft (SVG) lesions is controversial. Methods: This is an observational study comparing the incidence of target vessel revascularization, allcause death, myocardial infarction (MI), stroke and stent thrombosis in patients who underwent SVG percutaneous coronary intervention, us...
متن کاملLetter by Hakeem et al regarding article, "Drug-eluting or bare metal stents for the treatment of saphenous vein graft disease: a Bayesian meta-analysis".
متن کامل
Drug-Eluting Stents Versus Bare Metal Stents in Saphenous Vein Graft Intervention.
Percutaneous coronary intervention (PCI) of saphenous vein graft (SVG) is associated with higher adverse event rates, lower procedural success, and inferior longterm patency rates compared with native vessel PCI. The ability to comply with dual antiplatelet therapy, and whether the patient will need an interruption in dual antiplatelet therapy, should be considered when deciding whether to impl...
متن کاملA comparison of drug-eluting stents versus bare metal stents in saphenous vein graft PCI outcomes: a meta-analysis.
AIMS Studies demonstrate that percutaneous coronary intervention (PCI) with drug-eluting stents (DES) is associated with reduced revascularization and major adverse cardiac events (MACE) rates compared to bare metal stents (BMS) in native coronary vessels. Optimal PCI treatment of saphenous vein graft (SVG) lesions remains unclear despite SVG procedures representing up to 10% of PCI cases. We t...
متن کاملSecondary prevention, the interventional way: prophylactic drug-eluting stents for nonobstructive saphenous vein graft disease.
The pathophysiology of accelerated atherosclerosis in saphenous vein grafts (SVG) relates to progressive atheroma burden, neointimal hyperplasia, and vascular remodeling.1,2 Unfortunately, the therapeutic and clinical consequences of SVG disease are not trivial, and interventional cardiologists are wary of performing percutaneous coronary interventions (PCI) on degenerated SVG. Intervening on f...
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ورودعنوان ژورنال:
- The American journal of cardiology
دوره 105 8 شماره
صفحات -
تاریخ انتشار 2010