lectroencephalographic Alpha Measures Predict herapeutic Response to a Selective Serotonin euptake Inhibitor Antidepressant: Pre- and ost-Treatment Findings
نویسندگان
چکیده
ackground: There is growing evidence that individual differences among depressed patients on electrophysiologic (EEG), neuroim nd neurocognitive measures are predictive of therapeutic response to antidepressant drugs. This study replicates prior find retreatment differences between selective serotonin reuptake inhibitor (SSRI) responders and nonresponders in EEG alpha po symmetry and examines whether these differences normalize or are stable after treatment.
منابع مشابه
Current source density measures of electroencephalographic alpha predict antidepressant treatment response.
BACKGROUND Despite recent success in pharmacologic treatment of depression, the inability to predict individual treatment response remains a liability. This study replicates and extends findings relating pretreatment electroencephalographic (EEG) alpha to treatment outcomes for serotonergic medications. METHODS Resting EEG (eyes-open and eyes-closed) was recorded from a 67-electrode montage i...
متن کاملEEG alpha asymmetry as a gender-specific predictor of outcome to acute treatment with different antidepressant medications in the randomized iSPOT-D study.
OBJECTIVE To determine whether EEG occipital alpha and frontal alpha asymmetry (FAA) distinguishes outpatients with major depression (MDD) from controls, predicts antidepressant treatment outcome, and to explore the role of gender. METHODS In the international Study to Predict Optimized Treatment in Depression (iSPOT-D), a multi-center, randomized, prospective open-label trial, 1008 MDD parti...
متن کاملPrediction of Selective Serotonin Reuptake Inhibitor Response Using Diffusion-Weighted MRI
Pre-treatment differences in serotonergic binding between those who remit to antidepressant treatment and those who do not have been found using Positron Emission Tomography (PET). To investigate these differences, an exploratory study was performed using a second imaging modality, diffusion-weighted MRI (DW-MRI). Eighteen antidepressant-free subjects with Major Depressive Disorder received a 2...
متن کاملPredicting therapeutic response to secondary treatment with bupropion: dichotic listening tests of functional brain asymmetry.
Studies using neuroimaging, electrophysiologic and cognitive measures have raised hopes for developing predictors of therapeutic response to antidepressants. Pretreatment measures of functional brain asymmetry have been found to be related to response to the selective serotonin reuptake inhibitor fluoxetine. This report examines the extent to which dichotic listening tests also predict clinical...
متن کاملSadness and mild cognitive impairment as predictors for interferon-alpha-induced depression
plus ribavirin is established standard treatment of hepatitis C virus (HCV) infection. Antiviral therapy including IFN-a, however, is associated with significant psychiatric side-effects such as depressive symptoms, fatigue and insomnia. The reported prevalence of INF-associated major depressive episodes is 20–40%, and up to 70% of patients may develop mild to moderate depressive episodes with ...
متن کامل