Making of Vaccines against Human Chorionic Gonadotrophin for Control of Fertility of Women without Impairment of Ovulation and Menstrual Regularity

Reviewed briefly is the development of a unique vaccine against hCG, which prevents unwanted pregnancy without blocking ovulation and disturbing menstrual regularity. A recombinant version of this vaccine, amenable to largescale production by industry, in both DNA and protein form has been made. Priming with DNA followed by protein improves further its immunogenicity. Mycobacterium indicus pranii (MiP), a cultivable non-pathogenic mycobacteria has been used in the recombinant vaccine as a potent adjuvant. MiP was developed as an immunotherapeutic vaccine against leprosy. It is approved by the Drugs Controller General of India and USFDA, and has many additional applications in treatment of tuberculosis, curing of ugly ano-genital warts and in prevention and treatment of some cancers.