CCR-13-0487R A pharmacogenetic predictive model for paclitaxel clearance based on the DMET platform
نویسندگان
چکیده
Dept of Medical Oncology, Erasmus University Medical Center – Erasmus MC Cancer Institute, Rotterdam, the Netherlands; Dept of Clinical Chemistry, Erasmus University Medical Center, Rotterdam, the Netherlands; Dept of Pharmaceutical Sciences, St Jude Children’s Research Hospital, Memphis, TN; Dept of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden; Dept of Trials and Statistics, Erasmus University Medical Center, – Erasmus MC Cancer Institute, Rotterdam, the Netherlands
منابع مشابه
A pharmacogenetic predictive model for paclitaxel clearance based on the DMET platform.
PURPOSE Paclitaxel is used in the treatment of solid tumors and displays high interindividual variation in exposure. Low paclitaxel clearance could lead to increased toxicity during treatment. We present a genetic prediction model identifying patients with low paclitaxel clearance, based on the drug-metabolizing enzyme and transporter (DMET)-platform, capable of detecting 1,936 genetic variants...
متن کاملPredictive Biomarkers and Personalized Medicine A Pharmacogenetic Predictive Model for Paclitaxel Clearance Based on the DMET Platform
Purpose: Paclitaxel is used in the treatment of solid tumors and displays high interindividual variation in exposure. Low paclitaxel clearance could lead to increased toxicity during treatment. We present a genetic predictionmodel identifyingpatientswith lowpaclitaxel clearance, basedon thedrug-metabolizing enzyme and transporter (DMET)-platform, capable of detecting 1,936 genetic variants in 2...
متن کاملCYP3A4*22 genotype and systemic exposure affect paclitaxel-induced neurotoxicity.
PURPOSE Paclitaxel is used for the treatment of several solid tumors and displays a high interindividual variation in exposure and toxicity. Neurotoxicity is one of the most prominent side effects of paclitaxel. This study explores potential predictive pharmacokinetic and pharmacogenetic determinants for the onset and severity of neurotoxicity. EXPERIMENTAL DESIGN In an exploratory cohort of ...
متن کاملDMET™ (Drug Metabolism Enzymes and Transporters): a pharmacogenomic platform for precision medicine
In the era of personalized medicine, high-throughput technologies have allowed the investigation of genetic variations underlying the inter-individual variability in drug pharmacokinetics/pharmacodynamics. Several studies have recently moved from a candidate gene-based pharmacogenetic approach to genome-wide pharmacogenomic analyses to identify biomarkers for selection of patient-tailored thera...
متن کاملImplementation of Low-Cost Architecture for Control an Active Front End Rectifier
In AC-DC power conversion, active front end rectifiers offer several advantages over diode rectifiers such as bidirectional power flow capability, sinusoidal input currents and controllable power factor. A digital finite control set model predictive controller based on fixed-point computations of an active front end rectifier with unity displacement of input voltage and current to improve dynam...
متن کامل