Optical microangiography provides depth-resolved images of directional ocular blood perfusion in posterior eye segment.
نویسندگان
چکیده
In this paper, we demonstrate that the optical microangiography (OAMG) is capable of depth-resolved imaging of directional blood perfusion within both retinal and choroid in the posterior segment of human eye. The study uses an OMAG system operating at 840 nm with an imaging speed at 27,000 A-scans per second. Sequentially registered multiple OMAG projection maps of small areas ( approximately 1 mm x 1 mm) are combined to provide directional blood flow images for a larger field of view. It takes approximately 3.7 sec to image a small area (1 x 1 mm(2)), and approximately 2.5 min for a larger field (3 x 3 mm(2)). Finally, we show superior performance of OMAG in providing functional images of capillary level microcirculation at different depths of retina and choroid that correlate well with the standard retinal pathology.
منابع مشابه
High-resolution wide-field imaging of retinal and choroidal blood perfusion with optical microangiography.
We present high-resolution wide-field imaging of retinal and choroidal blood perfusion with optical microangiography (OMAG) technology. Based on spatial frequency analysis, OMAG is capable of visualizing the vascular perfusion map down to capillary-level resolution. An OMAG system operating at 840 nm is used with an A-scan rate of 27,000 Hz, axial resolution of 8 mum, and sensitivity of 98 dB. ...
متن کاملUltrahigh sensitive optical microangiography reveals depth-resolved microcirculation and its longitudinal response to prolonged ischemic event within skeletal muscles in mice.
The primary pathophysiology of peripheral arterial disease is associated with impaired perfusion to the muscle tissue in the lower extremities. The lack of effective pharmacologic treatments that stimulate vessel collateralization emphasizes the need for an imaging method that can be used to dynamically visualize depth-resolved microcirculation within muscle tissues. Optical microangiography (O...
متن کاملVolumetric and quantitative imaging of retinal blood flow in rats with optical microangiography
In this paper, we present methods for 3D visualization and quantitative measurements of retinal blood flow in rats by the use of optical microangiography imaging technique (OMAG). We use ultrahigh sensitive OMAG to provide high-quality 3D RBF perfusion maps in the rat eye, from which the Doppler angle, as well as the diameters of blood vessels, are evaluated. Estimation of flow velocity (i.e. a...
متن کاملOptical microangiography of retina and choroid and measurement of total retinal blood flow in mice
We present a novel application of optical microangiography (OMAG) imaging technique for visualization of depth-resolved vascular network within retina and choroid as well as measurement of total retinal blood flow in mice. A fast speed spectral domain OCT imaging system at 820nm with a line scan rate of 140 kHz was developed to image the posterior segment of eyes in mice. By applying an OMAG al...
متن کاملB-scan ultrasonography of ocular abnormalities: a review of 182 dogs
Ultrasonography is the only practical method for obtaining images of the posterior segment of the eye when the light-conducting media are opaque. In this study, 182 dogs with ocular abnormalities presented to the Department of Veterinary Surgery and Radiology from December 2008-August 2010 were included. All the animals were subjected to detailed ophthalmic examination and B-scan ultrasonograph...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Journal of biomedical optics
دوره 15 2 شماره
صفحات -
تاریخ انتشار 2010