Inflammatory status affects the antitumor activity of poly-epitope-peptide vaccination against the thymidylate synthase in metastatic colo-rectal cancer patients enrolled in TSPP/VAC-1 Phase Ib trial
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چکیده
Inflammatory status affects the antitumor activity of poly-epitope-peptide vaccination against the thymidylate synthase in metastatic colo-rectal cancer patients enrolled in TSPP/VAC-1 Phase Ib trial Pierpaolo Correale, Valerio Nardone, Cirino Botta, Elodia Martino, Pierpaolo Pastina, Cristina Ulivieri, Maria Grazia Rossetti, Antonella Fioravanti, Claudia Gandolfo, Francesco Carbone, Tatiana Cosima Baldari, Pierosandro Tagliaferri, Luigi Pirtoli, Maria Grazia Cusi
منابع مشابه
Immunological monitoring of metastatic colorectal cancer patients undergoing active specific immunotherapy with a poly-epitope peptide vaccine (TSPP) to thymidylate synthase in combination with GOLFIG chemoimmunotherapy regimen
Background: TSPP is a 27 poly-epitope peptide anti-cancer vaccine which includes the amino acidic sequences of 3 known CTL-epitopes with HLA-A(*)02.01 binding motifs, contained in the thymidylate synthase (TS), a tumourassociated enzyme antigen critical for DNA synthesis and repair. The immunological and antitumor activity of TSPP has already been tested in preclinical studies, whose results of...
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