Beyond VEGF: inhibition of the fibroblast growth factor pathway and antiangiogenesis.

نویسندگان

  • Christopher Lieu
  • John Heymach
  • Michael Overman
  • Hai Tran
  • Scott Kopetz
چکیده

Fibroblast growth factor (FGF) signaling regulates cell proliferation, differentiation, survival, angiogenesis, and wound healing. Compelling evidence for deregulated FGF signaling in tumorigenesis continues to emerge, and a growing body of research suggests that FGF may also play an integral role in the resistance to anti-VEGF therapy. Although agents targeting FGF signaling are early in development, the potential to target both the VEGF and FGF pathways may translate into improvements in the clinical care of cancer patients.

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عنوان ژورنال:
  • Clinical cancer research : an official journal of the American Association for Cancer Research

دوره 17 19  شماره 

صفحات  -

تاریخ انتشار 2011