Soluble tumor necrosis factor alpha receptors in sera from leprosy patients.

نویسندگان

  • M E Munk
  • P Anding
  • A P Schettini
  • M G Cunha
  • S H Kaufmann
چکیده

Serum levels of soluble tumor necrosis factor alpha receptor I (sTNF-RI) were elevated in patients with lepromatous (LL) reactional-state type II leprosy, and sTNF-RII levels were increased in patients with full tuberculoid (TT) or LL type II leprosy. The sTNF-R in sera from patients with type II leprosy, but not other forms of leprosy, inhibited recombinant TNF cytolytic activities in vitro. This suggests that sTNF-R regulatory activities are partially impaired in patients with leprosy.

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عنوان ژورنال:
  • Infection and immunity

دوره 67 1  شماره 

صفحات  -

تاریخ انتشار 1999